An active metabolite of BIBF 1120
Related Products
Parent Compound(s)
11022BIBF 1120 31082BIBF 1120 (esylate)
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BIBF 1202

Item No. 27176

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid
CAS Number
894783-71-2
Molecular Formula
C30H31N5O4
Formula Weight
525.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
CN(C(CN1CCN(C)CC1)=O)C(C=C2)=CC=C2N/C(C3=CC=CC=C3)=C4C(NC5=C\4C=CC(C(O)=O)=C5)=O
InChi Code
InChI=1S/C30H31N5O4/c1-33-14-16-35(17-15-33)19-26(36)34(2)23-11-9-22(10-12-23)31-28(20-6-4-3-5-7-20)27-24-13-8-21(30(38)39)18-25(24)32-29(27)37/h3-13,18,31H,14-17,19H2,1-2H3,(H,32,37)(H,38,39)/b28-27-
InChi Key
KEHNCEDHZGQSNP-DQSJHHFOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    BIBF 1202 is an active metabolite of the VEGFR, FGFR, and PDGFR inhibitor BIBF 1120 (nintedanib; Item No. 11022).1,2 It is formed from BIBF 1120 by intracellular esterases.1 BIBF 1202 inhibits VEGFR2 with an IC50 value of 62 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hilberg, F., Roth, G.J., Krssak, M., et al. BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68(12), 4774-4782 (2008).

    2. Lin, D., Qiao, L.M., Zhang, Y.N., et al. Simultaneous determination of nintedanib and its metabolite by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. J. Pharm. Biomed. Anal. 117, 173-177 (2016).