A peptide hormone
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Adrenomedullin (1-50) amide (rat) (trifluoroacetate salt)

Item No. 27208

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • ADM
  • AM
Molecular Formula
C242H381N77O75S5 • XCF3COOH
Formula Weight
5729.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC(CNC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](N3)CSSC[C@H](NC(CNC([C@@]([C@@H](C)O)([H])NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC(CNC([C@H](CCC(N)=O)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N[H])CC4=CC=C(O)C=C4)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C3=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)C)=O)CC6=CN=CN6)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)CC8=CC=CC=C8)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)CCSC)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC9=CC=C(O)C=C9)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C242H381N77O75S5.C2HF3O2/c1-16-118(5)188(232(388)306-156(97-130-56-62-134(330)63-57-130)217(373)292-147(67-73-175(251)334)210(366)301-157(96-127-40-22-19-23-41-127)223(379)316-193(125(12)327)236(392)307-163(103-187(348)349)222(378)285-138(44-26-30-81-245)205(361)305-162(102-186(346)347)221(377)284-137(43-25-29-80-244)204(360)304-161(101-185(344)345)200(356)272-105-180(339)278-150(76-89-395-13)201(357)277-121(8)237(393)318-87-36-50-170(318)229(385)295-143(49-35-86-269-242(263)264)207(363)302-159(99-178(254)337)219(375)286-139(45-27-31-82-246)214(370)313-189(119(6)17-2)233(389)310-167(113-323)238(394)319-88-37-51-171(319)230(386)296-145(65-71-173(249)332)198(354)270-106-181(340)279-153(194(256)350)94-129-54-60-133(329)61-55-129)314-215(371)149(69-75-177(253)336)293-218(374)158(98-131-104-265-116-275-131)298-195(351)120(7)276-216(372)154(92-117(3)4)299-203(359)136(42-24-28-79-243)283-209(365)146(66-72-174(250)333)291-212(368)152(78-91-397-15)297-235(391)192(124(11)326)317-228(384)169-115-399-398-114-168(227(383)288-141(47-33-84-267-240(259)260)206(362)300-155(95-126-38-20-18-21-39-126)199(355)273-109-184(343)312-191(123(10)325)234(390)311-169)281-183(342)108-274-231(387)190(122(9)324)315-226(382)166(112-322)309-208(364)142(48-34-85-268-241(261)262)287-224(380)164(110-320)280-182(341)107-271-197(353)144(64-70-172(248)331)289-220(376)160(100-179(255)338)303-213(369)151(77-90-396-14)294-225(381)165(111-321)308-211(367)148(68-74-176(252)335)290-202(358)140(46-32-83-266-239(257)258)282-196(352)135(247)93-128-52-58-132(328)59-53-128;3-2(4,5)1(6)7/h18-23,38-41,52-63,104,116-125,135-171,188-193,320-330H,16-17,24-37,42-51,64-103,105-115,243-247H2,1-15H3,(H2,248,331)(H2,249,332)(H2,250,333)(H2,251,334)(H2,252,335)(H2,253,336)(H2,254,337)(H2,255,338)(H2,256,350)(H,265,275)(H,270,354)(H,271,353)(H,272,356)(H,273,355)(H,274,387)(H,276,372)(H,277,357)(H,278,339)(H,279,340)(H,280,341)(H,281,342)(H,282,352)(H,283,365)(H,284,377)(H,285,378)(H,286,375)(H,287,380)(H,288,383)(H,2
InChi Key
HPXWDKJNPWDNLA-VVZZAKLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Adrenomedullin (1-50) is a peptide hormone with RNA expressed in rat adrenal glands, lung, kidney, heart, and spleen, as well as in the duodenum and submandibular glands.1 The rat amino acid sequence is similar to human adrenomedullin (1-52) (Item No. 24889) but lacks two amino acids and contains six substitutions. Adrenomedullin (1-50) increases cAMP concentration in rat platelets (ED50 = 50 nM) and decreases mean blood pressure in anesthetized rats when administered at an intravenous dose of 1 nmol/kg. It reduces vascular hyperpermeability and increases survival in a rat model of α-toxin-induced septic shock.2 Adrenomedullin (1-50) also inhibits binding of human adrenomedullin to rat astrocytes in vitro (IC50 = 0.27 nM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sakata, J., Shimokubo, T., Kitamura, K., et al. Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem. Biophys. Res. Commun. 195(2), 921-927 (1993).

    2. Temmesfeld-Wollbrück, T., Brell, B., Dávid, I., et al. Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Intensive Care Med. 33(4), 703-710 (2007).

    3. Zimmerman, U., Fischer, J.A., Frei, K., et al. Identification of adrenomedullin receptors in cultured rat astrocytes and in neuroblastboma x glioma hybrid cells (NG108-15). Brain Res. 724(2), 238-245 (1996).