A peptide derived from preproadrenomedullin
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Proadrenomedullin (45-92) (human) (trifluoroacetate salt)

Item No. 27209

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-L-leucyl-L-arginyl-L-methionyl-L-seryl-L-seryl-L-seryl-L-tyrosyl-L-prolyl-L-threonylglycyl-L-leucyl-L-alanyl-L-α-aspartyl-L-valyl-L-lysyl-L-alanylglycyl-L-prolyl-L-alanyl-L-glutaminyl-L-threonyl-L-leucyl-L-isoleucyl-L-arginyl-L-prolyl-L-glutaminyl-L-α-aspartyl-L-methionyl-L-lysylglycyl-L-alanyl-L-seryl-L-arginyl-L-seryl-L-prolyl-L-α-glutamyl-L-α-aspartyl-L-seryl-L-seryl-L-prolyl-L-α-aspartyl-L-alanyl-L-alanyl-L-arginyl-L-isoleucyl-L-arginyl-L-valine, trifluoroacetate salt
Synonyms
  • Mid-Regional proADM
  • Mid-Regional Proadrenomedullin
  • MR-proADM
  • MR-proAM
  • proADM
  • proAM
Molecular Formula
C215H359N67O73S2 • XCF3COOH
Formula Weight
5114.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
OC(C(F)(F)F)=O.[H]N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(N1CCC[C@H]1C(N[C@]([C@@H](C)O)([H])C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(NCC(N2CCC[C@H]2C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N4CCC[C@H]4C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)C)=O)C)=O)CC(O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CCSC)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)C)=O)=O)=O)CC(O)=O)=O)C)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O)=O)CCSC)=O)=O)=O
InChi Code
InChI=1S/C215H359N67O73S2.C2HF3O2/c1-25-104(13)162(203(347)256-122(46-34-72-234-214(227)228)181(325)273-161(103(11)12)210(354)355)274-182(326)121(45-33-71-233-213(225)226)246-169(313)109(18)240-167(311)108(17)242-185(329)132(85-156(302)303)262-199(343)147-51-39-78-282(147)209(353)143(98-289)271-195(339)141(96-287)267-188(332)134(87-158(306)307)261-178(322)125(60-64-155(300)301)254-198(342)146-50-38-77-281(146)208(352)142(97-288)270-176(320)120(44-32-70-232-212(223)224)250-191(335)137(92-283)265-168(312)107(16)239-151(295)89-236-173(317)117(41-27-29-67-216)248-179(323)126(65-79-356-23)252-187(331)133(86-157(304)305)260-177(321)123(58-61-149(219)293)253-197(341)145-49-37-75-279(145)206(350)128(47-35-73-235-215(229)230)257-204(348)163(105(14)26-2)275-189(333)131(83-101(7)8)263-205(349)165(113(22)291)276-183(327)124(59-62-150(220)294)247-170(314)111(20)244-196(340)144-48-36-74-278(144)153(297)91-238-166(310)106(15)241-174(318)118(42-28-30-68-217)255-202(346)160(102(9)10)272-190(334)135(88-159(308)309)258-171(315)110(19)243-184(328)129(81-99(3)4)245-152(296)90-237-201(345)164(112(21)290)277-200(344)148-52-40-76-280(148)207(351)136(84-114-53-55-115(292)56-54-114)264-192(336)138(93-284)268-194(338)140(95-286)269-193(337)139(94-285)266-180(324)127(66-80-357-24)251-175(319)119(43-31-69-231-211(221)222)249-186(330)130(82-100(5)6)259-172(316)116(218)57-63-154(298)299;3-2(4,5)1(6)7/h53-56,99-113,116-148,160-165,283-292H,25-52,57-98,216-218H2,1-24H3,(H2,219,293)(H2,220,294)(H,236,317)(H,237,345)(H,238,310)(H,239,295)(H,240,311)(H,241,318)(H,242,329)(H,243,328)(H,244,340)(H,245,296)(H,246,313)(H,247,314)(H,248,323)(H,249,330)(H,250,335)(H,251,319)(H,252,331)(H,253,341)(H,254,342)(H,255,346)(H,256,347)(H,257,348)(H,258,315)(H,259,316)(H,260,321)(H,261,322)(H,262,343)(H,263,349)(H,264,336)(H,265,312)(H,266,324)(H,267,332)(H,268,338)(H,269,337)(H,270,320)(H,271,339)(H,272,334)(H,273,325)(H,274,326)(H,275,333)(H,276,327)(H,277,344)(H,298,299)(H,300,301)(H,302,303)(H,304,305)(H,306,30
InChi Key
UFIWXFWPOIGMOB-SLMBDGCKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Proadrenomedullin (45-92) (MR-proADM) is a peptide that is comprised of amino acid residues 45-92 of preproadrenomedullin.1 MR-proADM has no effect on precontracted isolated cat pulmonary arterial rings when used at concentrations up to 10 μM, unlike adrenomedullin (1-52) (Item No. 24889) and adrenotensin, which induce relaxation and contraction, respectively.2 Levels of MR-proADM are elevated in the plasma of patients with sepsis and those with cardiovascular disease and positively correlate with disease severity in patients with community-acquired pneumonia.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morgenthaler, N.G., Struck, J., Alonso, C., et al. Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin. Chem. 51(10), 1823-1829 (2005).

    2. Gumusel, B., Chang, J.-K., Hyman, A., et al. Adrenotensin: An ADM gene product with the opposite effects of ADM. Life Sci. 57(8), PL87-PL90 (1995).

    3. Huang, D.T., Angus, D.C., Kellum, J.A., et al. Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia. Chest 136(3), 823-831 (2009).