An inhibitor of the MDM2 protein and XIAP RNA interaction
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MX69

Item No. 27224

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-benzoic acid
CAS Number
1005264-47-0
Molecular Formula
C27H26N2O4S
Formula Weight
474.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
OC(C1=CC=C(C2NC(C=CC(S(NC3=CC(C)=C(C)C=C3)(=O)=O)=C4)=C4C5C2CC=C5)C=C1)=O
InChi Code
InChI=1S/C27H26N2O4S/c1-16-6-11-20(14-17(16)2)29-34(32,33)21-12-13-25-24(15-21)22-4-3-5-23(22)26(28-25)18-7-9-19(10-8-18)27(30)31/h3-4,6-15,22-23,26,28-29H,5H2,1-2H3,(H,30,31)
InChi Key
XCBONKHCCRJMNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    MX69 is an inhibitor of the interaction between the ubiquitin ligase MDM2 protein and XIAP mRNA.1 It binds to the RING domain of MDM2 (Kd = 2.34 µM) and decreases the levels of MDM2 and XIAP in a concentration-dependent manner without affecting the levels of Bcl-2, cIAP-1, and cIAP-2. It induces autoubiquitination and degradation of MDM2 and increases the half-life of p53 in EU-1 cells. MX69 is cytotoxic to a variety of acute lymphoblastic leukemia (ALL) and neuroblastoma cancer cell lines but not to human normal bone marrow mononuclear (NBMM) cells. It increases survival in an EU-1 mouse model of leukemia when administered at a dose of 100 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gu, L., Zhang, H., Liu, T., et al. Discovery of dual inhibitors of MDM2 and XIAP for cancer treatment. Cancer Cell 30(4), 623-636 (2016).