A dopamine metabolite
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Homovanillic Acid

Item No. 27307

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-methoxy-benzeneacetic acid
CAS Number
306-08-1
Synonyms
  • HVA
  • NSC 16682
  • Vanilacetic Acid
Molecular Formula
C9H10O4
Formula Weight
182.2
Purity
≥98%
Emission
420 nm
Excitation
312 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/ml
λmax
231, 282 nm
SMILES
OC(CC1=CC(OC)=C(O)C=C1)=O
InChi Code
InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)
InChi Key
QRMZSPFSDQBLIX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $36

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    500 mg

    $53

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    1 g

    $70

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    Product Description

    Homovanillic acid (HVA) is a dopamine metabolite.1 It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; Item No. 24912) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively.2 It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Käenmaki, M., Tammimäki, A., Myöhänen, T., et al. Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. J. Neurochem. 114(6), 1745-1755 (2010).

    2. Ruch, W., Cooper, P.H., and Baggiolini, M. Assay of H2O2 production by macrophages and neutrophils with homovanillic acid and horse-radish peroxidase. J. Immunol. Methods 63(3), 347-357 (1983).