A melanocortin receptor agonist
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Melanotan II (acetate)

Item No. 27316

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2→7)-lactam, acetate
Synonyms
  • MT II
Molecular Formula
C50H69N15O9 • XC2H4O2
Formula Weight
1024.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 15 mg/mlEthanol: 1 mg/ml
SMILES
O=C(N[C@]([H])(C(N)=O)CCCCNC1=O)[C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CCCNC(N)=N)NC([C@](CC4=CC=CC=C4)([H])NC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@@H](NC(C)=O)CCCC)=O)C1)=O)=O)=O)=O.CC(O)=O
InChi Code
InChI=1S/C50H69N15O9.C2H4O2/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32;1-2(3)4/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56);1H3,(H,3,4)/t35-,36-,37-,38+,39-,40-,41-;/m0./s1
InChi Key
GTAMEWQATOUMGW-GBRHMYBBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $169

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    5 mg

    $753

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Melanotan II is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (Kis = 0.67, 34, 6.6, and 46 nM, respectively, in COS cells expressing human recombinant receptors).1 It improves recovery of sciatic nerve function after mechanical injury in rats, and increases cisplatin-induced decreases in sensory nerve conduction velocity when administered at a dose of 20, but not 2 or 50, µg/kg.2 Melanotan II (1 nmol, i.c.v.) increases oxygen consumption and protein levels of uncoupling protein 1 (UCP1) in brown adipose tissue homogenates and decreases food intake, body weight, and serum levels of leptin, glucose, insulin, and cholesterol (Item No. 9003100) in chow-fed and diet-induced obese rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schiöth, H.B., Müceniece, R., Mutulis, F., et al. Selectivity of cyclic [D-Nal7] and [D-Phe7] substituted MSH analogues for the melanocortin receptor subtypes. Peptides 18(7), 1009-1013 (1997).

    2. Ter Laak, M.P., Brakkee, J.H., Adamn, R.A., et al. The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur. J. Pharmacol. 462(1-3), 179-183 (2003).

    3. Li, G., Zhang, Y., Wilsey, J.T., et al. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J. Endocrinol. 182(1), 123-132 (2004).