A VPS34 inhibitor
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Autophinib

Item No. 27320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine
CAS Number
1644443-47-9
Molecular Formula
C14H11ClN6O3
Formula Weight
346.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
ClC1=CC(NC2=NNC(C)=C2)=NC(OC3=CC=C([N+]([O-])=O)C=C3)=N1
InChi Code
InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20)
InChi Key
CEUMAXLRGBKFQP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $83

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    10 mg

    $110

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    25 mg

    $207

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    Product Description

    Autophinib is an ATP-competitive inhibitor of the PI3K VPS34 (IC50 = 19 nM).1 It inhibits autophagy induced by the mTOR inhibitor rapamycin (Item No. 13346) or by amino acid starvation (IC50s = 40 and 90 nM, respectively) in MCF-7 cells. Autophinib also induces apoptosis in amino acid-starved MCF-7 cells with an EC50 value of 234 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robke, L., Laraia, L., Carnero Corrales, M.A., et al. Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew. Chem. Int. Ed. Engl. 56(28), 8153-8157 (2017).