A COX inhibitor and NSAID
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tiaprofenic Acid

Item No. 27364

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-benzoyl-α-methyl-2-thiopheneacetic acid
CAS Number
33005-95-7
Synonyms
  • RU 15060
  • Tiaprofen
Molecular Formula
C14H12O3S
Formula Weight
260.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15mg/mLDMSO: 20mg/mLEthanol: 20mg/mLEthanol:PBS (pH 7.2) (1:10): 0.09mg/mL
λmax
303 nm
SMILES
O=C(C1=CC=C(C(C)C(O)=O)S1)C2=CC=CC=C2
InChi Code
InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)
InChi Key
GUHPRPJDBZHYCJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $36

    Add

    10 mg

    $68

    Add

    50 mg

    $236

    Add

    100 mg

    $436

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.1 It inhibits synthesis of prostaglandin E2 (PGE2; Item No. 14010) and PGF2α (Item Nos. 16010 | 16020) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in bovine seminal vesicle microsomes and inhibits thromboxane B2 (TXB2; Item No. 19030) formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).2,1 Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sorkin, E.M., and Brogden, R.N. Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. Drugs 29(3), 208-235 (1985).

    2. Schrör, K., and Seidel, H. Blood-vessel wall arachidonate metabolism and its pharmacological modification in a new in vitro assay system. Naunyn Schmiedebergs Arch. Pharmacol. 337(2), 177-182 (1988).