A COX inhibitor and NSAID
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Tiaprofenic Acid

Item No. 27364

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-benzoyl-α-methyl-2-thiopheneacetic acid
CAS Number
33005-95-7
Synonyms
  • RU 15060
  • Tiaprofen
Molecular Formula
C14H12O3S
Formula Weight
260.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15mg/mLDMSO: 20mg/mLEthanol: 20mg/mLEthanol:PBS (pH 7.2) (1:10): 0.09mg/mL
λmax
303 nm
SMILES
O=C(C1=CC=C(C(C)C(O)=O)S1)C2=CC=CC=C2
InChi Code
InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)
InChi Key
GUHPRPJDBZHYCJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $68

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    50 mg

    $236

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    100 mg

    $436

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    Product Description

    Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.1 It inhibits synthesis of prostaglandin E2 (PGE2; Item No. 14010) and PGF2α (Item Nos. 16010 | 16020) from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in bovine seminal vesicle microsomes and inhibits thromboxane B2 (TXB2; Item No. 19030) formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).2,1 Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sorkin, E.M., and Brogden, R.N. Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. Drugs 29(3), 208-235 (1985).

    2. Schrör, K., and Seidel, H. Blood-vessel wall arachidonate metabolism and its pharmacological modification in a new in vitro assay system. Naunyn Schmiedebergs Arch. Pharmacol. 337(2), 177-182 (1988).