An NSAID and selective COX-2 inhibitor
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Isomer(s)
33994Hydroxy Celecoxib
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Deracoxib

Item No. 27371

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl]-benzenesulfonamide
CAS Number
169590-41-4
Synonyms
  • SC-59046
Molecular Formula
C17H14F3N3O3S
Formula Weight
397.4
Purity
≥98%
Formulation (Request formulation change)
A solid
λmax
256 nm
SMILES
FC1=CC(C2=CC(C(F)F)=NN2C3=CC=C(S(N)(=O)=O)C=C3)=CC=C1OC
InChi Code
InChI=1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25)
InChi Key
WAZQAZKAZLXFMK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $41

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    50 mg

    $75

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    100 mg

    $134

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    250 mg

    $312

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    Product Description

    Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) and selective inhibitor of COX-2 (IC50s = 0.63 and 23 μM for COX-2 and COX-1, respectively).1 In vivo, deracoxib (0.3-10 mg/kg) increases weight bearing and decreases lameness and joint effusion in a canine model of urate crystal-induced intraarticular synovitis.2 Deracoxib induces less lesion formation in the gastric mucosa of healthy canines than aspirin (Item No. 70260) when administered at a dose of 1.5 mg/kg.3 Formulations containing deracoxib have been used in the treatment of pain associated with canine osteoarthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, J., DeMello, K.M.L., Cheng, H., et al. Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine. Bioorg. Med. Chem. Lett. 14(1), 95-98 (2004).

    2. Millis, D.L., Weigel, J.P., Moyers, T., et al. Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. Vet. Ther. 3(4), 453-464 (2002).

    3. Sennello, K.A., and Leib, M.S. Effects of deracoxib or buffered aspirin on the gastric mucosa of healthy dogs. J. Vet. Intern. Med. 20(6), 1291-1296 (2006).