A peptide fragment of preproadrenomedullin
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Product Type

Biochemicals
Peptides
Peptide Hormones

Proadrenomedullin (N-20) (bovine, porcine) (trifluoroacetate salt)

Item No. 27407

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-arginyl-L-leucyl-L-α-aspartyl-L-valyl-L-alanyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl-L-argininamide, trifluoroacetate salt
Synonyms
  • Mid-Regional proADM
  • Mid-Regional Proadrenomedullin
  • MR-proADM
  • MR-proAM
  • proADM
  • ProAM
Molecular Formula
C112H178N36O26 • XCF3COOH
Formula Weight
2444.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N[H])C)=O)=O)=O)CC(O)=O)=O)=O)C)=O)C)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)C)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C112H178N36O26.C2HF3O2/c1-57(2)47-78(103(168)147-85(56-149)108(173)133-71(90(118)155)36-24-44-125-110(119)120)140-94(159)63(10)131-101(166)81(50-65-54-128-69-31-16-14-29-67(65)69)143-98(163)74(35-20-23-43-115)138-106(171)83(52-86(117)150)145-105(170)82(51-66-55-129-70-32-17-15-30-68(66)70)144-97(162)73(34-19-22-42-114)137-95(160)72(33-18-21-41-113)136-96(161)76(38-26-46-127-112(123)124)139-104(169)80(49-64-27-12-11-13-28-64)142-100(165)77(39-40-87(151)152)135-93(158)62(9)130-92(157)61(8)132-109(174)89(59(5)6)148-107(172)84(53-88(153)154)146-102(167)79(48-58(3)4)141-99(164)75(134-91(156)60(7)116)37-25-45-126-111(121)122;3-2(4,5)1(6)7/h11-17,27-32,54-55,57-63,71-85,89,128-129,149H,18-26,33-53,56,113-116H2,1-10H3,(H2,117,150)(H2,118,155)(H,130,157)(H,131,166)(H,132,174)(H,133,173)(H,134,156)(H,135,158)(H,136,161)(H,137,160)(H,138,171)(H,139,169)(H,140,159)(H,141,164)(H,142,165)(H,143,163)(H,144,162)(H,145,170)(H,146,167)(H,147,168)(H,148,172)(H,151,152)(H,153,154)(H4,119,120,125)(H4,121,122,126)(H4,123,124,127);(H,6,7)/t60-,61-,62-,63-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,89-;/m0./s1
InChi Key
IAXUOMCMHWIEGV-LTLLRERZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Proadrenomedullin (N-20) is an endogenous peptide consisting of the 20 N-terminal amino acids of proadrenomedullin, which also corresponds to amino acids 22-41 of preproadrenomedullin.1,2,3 Proadrenomedullin (N-20) has been found in porcine adrenal medulla.3 The porcine and bovine proadrenomedullin (N-20) amino acid sequence is similar to human proadrenomedullin (N-20) (Item No. 27102) but contains a substitution at position 7.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kitamura, K., Kangawa, K., Kojima, M., et al. Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor. FEBS Lett. 338(3), 306-310 (1994).

    2. Barker, S., Wood, E., Clark, A.J., et al. Cloning of bovine preproadrenomedullin and inhibition of its basal expression in vascular endothelial cells by staurosporine. Life Sci. 62(16), 1407-1415 (1998).

    3. Kitamura, K., Kangawa, K., Ishiyama, Y., et al. Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide (PAMP). FEBS Lett. 351(1), 35-37 (1994).