A fluorescently labeled amyloid-β peptide
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5-FAM-Amyloid-β (1-42) Peptide (human) (trifluoroacetate salt)

Item No. 27408

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • 5-FAM-Aβ (1-42)
  • 5-FAM-Aβ42
Molecular Formula
C224H321N55O66S • XCF3COOH
Formula Weight
4872.4
Purity
≥95%
Emission
518 nm
Excitation
492 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C(N([H])[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(O)=O)C)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)C)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CN=CN4)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)CC(O)=O)=O)CC6=CN=CN6)=O)=O)CC7=CC=CC=C7)=O)=O)C)=O)CC(O)=O)C8=CC(C(O)=O)=C(C9=C(C=C%10)C(OC%11=C9C=CC(O)=C%11)=CC%10=O)C=C8.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C224H321N55O66S.C2HF3O2/c1-28-115(20)183(215(334)240-100-167(290)248-145(77-107(4)5)201(320)258-144(72-76-346-27)198(317)272-177(109(8)9)213(332)238-96-164(287)235-97-169(292)271-179(111(12)13)218(337)276-182(114(18)19)219(338)279-184(116(21)29-2)220(339)247-121(26)222(341)342)278-221(340)185(117(22)30-3)277-188(307)118(23)244-165(288)98-236-190(309)137(51-40-42-73-225)253-208(327)154(89-163(228)286)265-212(331)159(103-281)250-168(291)101-239-214(333)178(110(10)11)273-211(330)157(92-175(303)304)266-196(315)142(66-70-171(295)296)252-186(305)119(24)245-199(318)148(79-122-45-34-31-35-46-122)262-204(323)150(81-124-49-38-33-39-50-124)268-216(335)181(113(16)17)275-210(329)146(78-108(6)7)260-192(311)138(52-41-43-74-226)254-194(313)140(64-68-162(227)285)256-205(324)151(84-127-93-231-104-241-127)264-207(326)153(86-129-95-233-106-243-129)269-217(336)180(112(14)15)274-197(316)143(67-71-172(297)298)257-202(321)147(82-125-54-57-130(282)58-55-125)249-166(289)99-237-191(310)158(102-280)270-209(328)156(91-174(301)302)267-206(325)152(85-128-94-232-105-242-128)263-193(312)139(53-44-75-234-224(229)230)255-203(322)149(80-123-47-36-32-37-48-123)261-195(314)141(65-69-170(293)294)251-187(306)120(25)246-200(319)155(90-173(299)300)259-189(308)126-56-61-133(136(83-126)223(343)344)176-134-62-59-131(283)87-160(134)345-161-88-132(284)60-63-135(161)176;3-2(4,5)1(6)7/h31-39,45-50,54-63,83,87-88,93-95,104-121,137-159,177-185,280-283H,28-30,40-44,51-53,64-82,84-86,89-92,96-103,225-226H2,1-27H3,(H2,227,285)(H2,228,286)(H,231,241)(H,232,242)(H,233,243)(H,235,287)(H,236,309)(H,237,310)(H,238,332)(H,239,333)(H,240,334)(H,244,288)(H,245,318)(H,246,319)(H,247,339)(H,248,290)(H,249,289)(H,250,291)(H,251,306)(H,252,305)(H,253,327)(H,254,313)(H,255,322)(H,256,324)(H,257,321)(H,258,320)(H,259,308)(H,260,311)(H,261,314)(H,262,323)(H,263,312)(H,264,326)(H,265,331)(H,266,315)(H,267,325)(H,268,335)(H,269,336)(H,270,328)(H,271,292)(H,272,317)(H,273,330)(H,274,316)(H,275,329)(H,276,337)(H,277,307)(H,278,3
InChi Key
IIQPCZNWLHDKNE-WPBKYADUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $616

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    Product Description

    5-FAM-Amyloid-β (1-42) peptide is a fluorescently labeled amyloid-β peptide. Amyloid-β (1-42) (Aβ42) peptide (Item No. 20574) is the primary form of Aβ found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease and its aggregation results in the formation of neurotoxic fibrils or globular oligomers.1,2 5-FAM-Amyloid-β (1-42) is a labeled form of Aβ42 containing 5-carboxyfluorescein (5-FAM; Item No. 19581), which displays excitation/emission maxima of 492/518 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wolfe, M.S. Therapeutic strategies for Alzheimer’s disease. Nat. Rev. Drug Discov. 1(11), 859-866 (2002).

    2. Iwatsubo, T., Odaka, A., Suzuki, N., et al. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43). Neuron 13(1), 45-53 (1994).