A caspase-3 inhibitor
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Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt)

Item No. 27427

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-valinamide, trifluoroacetate salt
Synonyms
  • Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
  • Ac-AAVALLPAVLLALLAP-DEVD-aldehyde
  • Ac-AAVALLPAVLLALLAPDEVD-CHO
  • Caspase-3 Inhibitor I
  • DEVD-CHO-CPP 32
Molecular Formula
C94H158N20O27 • XCF3COOH
Formula Weight
2000.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
CC(C)[C@@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N2CCC[C@H]2C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)C(C)C)=O)CCC(O)=O)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O)CC(C)C)=O)C(C)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)NC([C@H](C)NC([C@H](C)NC(C)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C94H158N20O27.C2HF3O2/c1-43(2)34-61(82(129)97-53(20)77(124)103-63(36-45(5)6)84(131)106-62(35-44(3)4)83(130)100-57(24)93(140)113-32-26-29-69(113)89(136)107-66(41-72(121)122)87(134)102-60(30-31-70(117)118)81(128)112-74(50(15)16)91(138)101-59(42-115)40-71(119)120)105-85(132)65(38-47(9)10)108-92(139)75(51(17)18)111-80(127)56(23)98-88(135)68-28-27-33-114(68)94(141)67(39-48(11)12)109-86(133)64(37-46(7)8)104-78(125)54(21)99-90(137)73(49(13)14)110-79(126)55(22)96-76(123)52(19)95-58(25)116;3-2(4,5)1(6)7/h42-57,59-69,73-75H,26-41H2,1-25H3,(H,95,116)(H,96,123)(H,97,129)(H,98,135)(H,99,137)(H,100,130)(H,101,138)(H,102,134)(H,103,124)(H,104,125)(H,105,132)(H,106,131)(H,107,136)(H,108,139)(H,109,133)(H,110,126)(H,111,127)(H,112,128)(H,117,118)(H,119,120)(H,121,122);(H,6,7)/t52-,53-,54-,55-,56-,57-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,73-,74-,75-;/m0./s1
InChi Key
UUACDJMODMQION-UWOLOOPLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $112

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    1 mg

    $212

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    Product Description

    Ac-AAVALLPAVLLALLAP-DEVD-CHO is a composite of Ac-DEVD-CHO (Item No. 10017), a peptide inhibitor of caspase-3 and -7, and a cell-permeable hydrophobic sequence derived from K-FGF.1,2,3 It is an inhibitor of caspase-3 that reduces caspase-3 activity and apoptosis induced by prostaglandin E2 (PGE2; Item No. 14010) in rat cortical neurons when used at concentrations ranging from 1 to 2.5 μM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. The Journal of Biological Chemisty 273(49), 32608-32613 (1998).

    2. Talanian, R.V., Quinlan, C., Trautz, S., et al. Substrate specificities of caspase family proteases. The Journal of Biological Chemisty 272(15), 9677-9682 (1997).

    3. Lin, Y.Z., Tao, S., Veach, R.A., et al. Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. The Journal of Biological Chemisty 270(24), 14255-14258 (1995).

    4. Takadera, T., Yumoto, H., Tozuka, Y., et al. Prostaglandin E2 induces caspase-dependent apoptosis in rat cortical cells. Neurosci. Lett. 317(2), 61-64 (2002).