Loureirin B

Loureirin B is a flavonoid originally isolated from D. cochinchinensis, a major component of the traditional herbal medicine dragon's blood, and has diverse biological activities.^1,2,3 It inhibits K_v1.3-mediated currents, induces membrane depolarization, and reduces calcium influx in Jurkat T cells.¹ It also inhibits phytohemagglutinin-induced IL-2 release from these cells. Loureirin B (25 μg/ml) reduces type I collagen and fibronectin protein levels in TGF-β1-stimulated fibroblasts as well as contraction of TGF-β1-stimulated fibroblasts in a gel contraction assay.² It reduces type I collagen and fibronectin protein levels and inhibits phosphorylation of ERK and JNK in isolated human hypertrophic scar tissue. Loureirin B increases glucose absorption and intracellular ATP levels in Ins-1 cells via inhibition of the K_ATP current and intracellular influx of calcium.³

WARNING This product is not for human or veterinary use.

1. Yin, S., Hu, Q., Luo, J., et al. Loureirin B, an essential component of Sanguis Draxonis, inhibits K_v1.3 channel and suppresses cytokine release from Jurkat T cells. Cell Biosci. 4, 78 (2014).

2. He, T., Bai, X., Yang, L., et al. Loureirin B inhibits hypertrophic scar formation via inhibition of the TGF-β1-ERK/JNK pathway. Cell Physiol. Biochem. 37(2), 666-676 (2015).

3. Sha, Y., Zhang, Y., Cao, J., et al. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium. J. Cell. Biochem. 119(2), 2012-2021 (2017).