Bostrycin

Bostrycin is an anthraquinone originally isolated from B. alpestre that has diverse biological activities, including antibacterial, antiproliferative, and phytotoxic properties.^1,2 It is active against Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum.² Bostrycin inhibits proliferation of A549 lung adenocarcinoma cells when used at concentrations ranging from 10 to 30 µM, as well as halts the cell cycle at the G₀/G₁ phase and induces apoptosis in A549 cells.³ It is a phytotoxin that induces necrosis of water hyacinth leaves when used at a concentration of approximately 7 µg/ml.⁴ Bostrycin has been used as a cross-linking agent for protein immobilization that retains bacteriostatic activity when immobilized on nonwoven polypropylene fabric.²

WARNING This product is not for human or veterinary use.

1. Noda, T., Take, T., Otani, M., et al. Structure of bostrycin. Tetrahedron Lett. 9(58), 6087-6090 (1968).

2. Yang, W.J., Yang, C.S., Huang, C.J., et al. Bostrycin, a novel coupling agent for protein immobilization and prevention of biomaterial-centered infection produced by Nigrospora sp. No. 407. Enzyme Microb. Technol. 50(6-7), 287-292 (2012).

3. Chen, W.S., Hou, J.N., Guo, Y.B., et al. Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway. J. Exp. Clin. Cancer Res. 30(1), 17 (2011).

4. Charudattan, R., and Rao, K.V. Bostrycin and 4-deoxybostrycin: Two nonspecific phytotoxins produced by Alternaria eichhorniae. Appl. Environ. Microbiol. 43(4), 846-849 (1982).