An antimalarial compound
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BQR-695

Item No. 27482

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl]amino]-N-methyl-acetamide
CAS Number
1513879-21-4
Molecular Formula
C19H20N4O3
Formula Weight
352.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
COC1=C(OC)C=CC(C2=CC=C(N=CC(NCC(NC)=O)=N3)C3=C2)=C1
InChi Code
InChI=1S/C19H20N4O3/c1-20-19(24)11-22-18-10-21-14-6-4-12(8-15(14)23-18)13-5-7-16(25-2)17(9-13)26-3/h4-10H,11H2,1-3H3,(H,20,24)(H,22,23)
InChi Key
LYPCULYCGFOIDA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $332

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    Product Description

    BQR-695 is an antimalarial compound.1 It inhibits recombinant P. vivax and human phosphatidylinositol 4-kinase (PI4K; IC50s = 3.5 and 90 nM, respectively). BQR-695 induces schizont-stage arrest and death of P. falciparum (IC50 = ~70 nM) without inducing cytotoxicity in mature red blood cells (RBCs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McNamara, C.W., Lee, M.C., Lim, C.S., et al. Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malaria. Nature 504(7479), 248-253 (2013).

    Product Citations

    von Krusenstiern, A.N., Robson, R.N., Qian, N., et al. Identification of essential sites of lipid peroxidation in ferroptosis. Nat. Chem. Biol. 19(6), 719-730 (2023).