A fungal metabolite
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Enantiomer(s)
18647(±)-Taxifolin
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Globosuxanthone A

Item No. 27486

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,2R)-2,9-dihydro-1,2,8-trihydroxy-9-oxo-1H-xanthene-1-carboxylic acid, methyl ester
CAS Number
917091-74-8
Molecular Formula
C15H12O7
Formula Weight
304.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: 1 mg/mlMethanol: Soluble
SMILES
OC1=C2C(OC(C=C[C@@H](O)[C@@]3(O)C(OC)=O)=C3C2=O)=CC=C1
InChi Code
InChI=1S/C15H12O7/c1-21-14(19)15(20)10(17)6-5-9-12(15)13(18)11-7(16)3-2-4-8(11)22-9/h2-6,10,16-17,20H,1H3/t10-,15+/m1/s1
InChi Key
HEFOWMGZUBJFBY-BMIGLBTASA-N
Origin
Fungus/Unidentified sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

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    5 mg

    $926

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    Cayman Chemical
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    Product Description

    Globosuxanthone A is a fungal metabolite originally isolated from C. globosum.1 It is cytotoxic to various human solid tumor cell lines, including MCF-7, PC3, LNCap, and DU145 cells (IC50s = 1.3, 0.65, 1.5, and 1.2 µM, respectively). It induces accumulation of cells in the G2/M and S phases of the cell cycle in NCI-H460 and PC3M cells. Globosuxanthone A is also active against C. albicans but not S. aureus, E. coli, or M. hiemalis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wijeratne, E.M.K., Turbyville, T.J., Fritz, A., et al. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorg. Med. Chem. 14(23), 7917-7923 (2006).

    2. Yamazaki, H., Rotinsulu, H., Kaneko, T., et al. A new dibenz[b,e]oxepine derivative, 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a marine-derived fungus, Beauveria bassiana TPU942. Mar. Drugs 10(12), 2691-2697 (2012).