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9(R)-Hexahydrocannabinol

Item No. 27500

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 9β-Hexahydrocannabinol
  • 11β-Hexahydrocannabinol
  • 9β-HHC
  • 9(R)-HHC
  • 11β-HHC
  • trans-(6aR,9R,10aR)-HHC
Technical Information
Formal Name
6aR,7,8,9R,10,10aR-hexahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol
CAS Number
36403-90-4
Molecular Formula
C21H32O2
Formula Weight
316.5
Purity
≥98%
Formulation
A 10 mg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: 10 mg/ml
SMILES
CC1(C)[C@@]2([H])[C@](C[C@H](C)CC2)([H])C3=C(C=C(CCCCC)C=C3O)O1
InChi Code
InChI=1S/C21H32O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h12-14,16-17,22H,5-11H2,1-4H3/t14-,16-,17-/m1/s1
InChi Key
XKRHRBJLCLXSGE-DJIMGWMZSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    9(R)-Hexahydrocannabinol (Item No. 27500) is an analytical reference standard that is structurally similar to known phytocannabinoids. 9(R)-Hexahydrocannabinol induces immobility, severe stupor, ataxia, full ptosis, and crouched posture, markers of psychotropic activity, in rhesus monkeys.1 9(R)-Hexahydrocannabinol is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mechoulam, R., Lander, N., Varkony, T.H., et al. Stereochemical requirements for cannabinoid activity. J. Med. Chem. 23(10), 1068-1072 (1980).

    Product Citations

    Lucuta, L., Schwarz, L., Liut, J., et al. Inhalation and oral administration of HHC products - Quantification of (9R)-, (9S)-Hexahydrocannabinol and metabolites in plasma and detectability in on-site drug tests for urine and oral fluid. Forensic Sci. Int. 370, 112437 (2025).

    Monti, M.C., Stoll, A., Schlotterbeck, G., et al. Miniaturized one-step extraction for the analysis of tetrahydrocannabinol ∆9- and ∆8- isomers, phytocannabinoids, and hexahydrocannabinol in whole blood using liquid chromatography tandem mass spectrometry. J. Chromatogr. A. 1760, 466276 (2025).

    Schirmer, W., Walton, S.E., Weinmann, W., et al. Rapid LC-QTOF-MS screening method for semi-synthetic cannabinoids in whole blood. J. Anal. Toxicol. bkaf095 (2025).

    Lindbom, K., Norman, C., Baginski, S., et al. Human metabolism of the semi-synthetic cannabinoids hexahydrocannabinol, hexahydrocannabiphorol and their acetates using hepatocytes and urine samples. Drug Test Anal. (2024).

    Janssens, L.K., Van Uytfanghe, K., Williams, J.B., et al. Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs. Arch. Toxicol. (2024).

    Pitterl, F., Pavlic, M., Liu, J., et al. Insights into the human metabolism of hexahydrocannabinol by non-targeted liquid chromatography-high-resolution tandem mass spectrometry. J. Anal. Toxicol. bkae022 (2024).

    Ujváry, I. Hexahydrocannabinol and closely related semi-synthetic cannabinoids: A comprehensive review. Drug Test. Anal. (2023).