A phenolic ketone with diverse biological activities
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6-Paradol

Item No. 27554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-hydroxy-3-methoxyphenyl)-3-decanone
CAS Number
27113-22-0
Molecular Formula
C17H26O3
Formula Weight
278.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
SMILES
O=C(CCCCCCC)CCC1=CC(OC)=C(O)C=C1
InChi Code
InChI=1S/C17H26O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h10,12-13,19H,3-9,11H2,1-2H3
InChi Key
CZNLTCTYLMYLHL-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $107

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    50 mg

    $203

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    100 mg

    $381

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    250 mg

    $845

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    Cayman Chemical
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    Product Description

    6-Paradol is a phenolic ketone that has been found in ginger (Z. officinale) and has diverse biological activities, including antioxidant, anti-inflammatory, and anti-hyperglycemic properties.1,2,3 It inhibits hydrogen peroxide-induced oxidation of cell-free calf thymus DNA when used at a concentration of 100 μM.1 In vitro, 6-paradol (10 μg/ml) inhibits LPS-induced nitric oxide (NO), IL-6, and TNF-α production by mouse BV-2 microglia.2 In vivo, 6-paradol (6.75 mg/kg per day) lowers blood glucose levels in an oral glucose tolerance test (OGTT) and inhibits weight-gain in a mouse model of high-fat diet-induced obesity.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chung, W.-Y., Jung, Y.-J., Surh, Y.-J., et al. Antioxidative and antitumor promoting effects of [6]-paradol and its homologs. Mutat. Res. 496(1), 199-206 (2001).

    2. Gaire, B.P., Kwon, O.W., Park, S.H., et al. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One 10(3), e0120203 (2015).

    3. Wei, C.-K., Tsai, Y.-H., Korinek, M., et al. 6-Paradol and 6-shogaol, the pungent compounds of ginger promote glucose utilization in adipocytes and mytotubes, and 6-paradol reduces blood glucose in high-fat diet-fed mice. Int. J. Mol. Sci. 18(1), E168 (2017).