A bacterial metabolite with antimicrobial activity
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OM173-αA

Item No. 27570

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,3R)-3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid, methyl ester
CAS Number
58286-56-9
Synonyms
  • Nanaomycin αA
  • Nanaomycin A methyl ester
Molecular Formula
C17H16O6
Formula Weight
316.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: 1 mg/mlMethanol: Soluble
SMILES
OC1=C2C(C(C(C[C@H](CC(OC)=O)O[C@H]3C)=C3C2=O)=O)=CC=C1
InChi Code
InChI=1S/C17H16O6/c1-8-14-11(6-9(23-8)7-13(19)22-2)16(20)10-4-3-5-12(18)15(10)17(14)21/h3-5,8-9,18H,6-7H2,1-2H3/t8-,9+/m0/s1
InChi Key
FMEUWIKCSICJBO-DTWKUNHWSA-N
Origin
Bacterium/Streptomyces rosa, Notoensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    OM173-αA is a quinone bacterial metabolite originally isolated from Streptomyces that has antimicrobial activity.1,2 It inhibits the growth of the bacteria M. gallisepticum, M. pneumoniae, and S. aureus in vitro with MIC values ranging from 0.39 to 3.13 μg/ml. OM173-αA also inhibits the growth of the plant pathogenic fungus P. oryzae (MIC = 3.12 μg/ml) and several species of Trichophyton (MICs = 12.5-25 μg/ml).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwai, Y., Kimura, K., Takahashi, Y., et al. OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties. J. Antibiot. (Tokyo) 36(10), 1268-1274 (1983).

    2. Liu, C., Lei, H., Chen, X., et al. Four new nanaomycins produced by Streptomyces hebeiensis derived from lichen. Chem. Biodivers. 14(7), (2017).