An anticonvulsant
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Seizure Disorders

Phensuximide

Item No. 27601

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-3-phenyl-2,5-pyrrolidinedione
CAS Number
86-34-0
Synonyms
  • (±)-Phensuximide
Molecular Formula
C11H11NO2
Formula Weight
189.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 15 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.1 mg/mlEthanol: 10 mg/ml
SMILES
O=C(N1C)C(C2=CC=CC=C2)CC1=O
InChi Code
InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3
InChi Key
WLWFNJKHKGIJNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $41

    Add

    10 mg

    $72

    Add

    25 mg

    $157

    Add
    Product Description

    Phensuximide is an anticonvulsant.1 It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole (Item No. 18682) in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats.2 Formulations containing phensuximide have been used in the treatment of petit mal seizures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kornet, M.J., Crider, A.M., and Magarian, E.O. Potential long-acting anticonvulsants. 1. Synthesis and activity of succinimides containing an alkylating group at the 2 position. J. Med. Chem. 20(3), 405-409 (1977).

    2. Rankin, G.O., Cressey-Veneziano, K., Wang, R.T., et al. Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. J. Appl. Toxicol. 6(5), 349-356 (1986).