An internal standard for the quantification of climbazole
Related Products
Unlabeled Version(s)
27968(±)-Climbazole
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(±)-Climbazole-d4

Item No. 27616

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorophenoxy-2,3,5,6-d4)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
CAS Number
1185117-79-6
Molecular Formula
C15H13ClD4N2O2
Formula Weight
296.8
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleMethanol: sparingly soluble
SMILES
CC(C)(C)C(C(OC1=C([2H])C([2H])=C(Cl)C([2H])=C1[2H])N2C=CN=C2)=O
InChi Code
InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3/i4D,5D,6D,7D
InChi Key
OWEGWHBOCFMBLP-UGWFXTGHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $218

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    (±)-Climbazole-d4 is intended for use as an internal standard for the quantification of climbazole by GC- or LC-MS. Climbazole is an imidazole antifungal.1 It inhibits the growth of C. albicans (MIC = 0.29 μg/ml) and various strains of M. pachydermatis (MICs = <0.06-1 μg/ml).2,3 (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.4 Formulations containing climbazole have been used in the treatment of dandruff.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Paz-Alvarez, M., Pudney, P.D.A., Hadgraft, J., et al. Topical delivery of climbazole to mammalian skin. Int. J. Pharm. 549(1-2), 317-324 (2018).

    2. Stylianou, M., Kulesskiy, E., Lopes, J.P., et al. Antifungal application of nonantifungal drugs. Antimicrob. Agents Chemother. 58(2), 1055-1062 (2014).

    3. Schmidt, A. In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis. Zentralbl. Veterinarmed. B 44(4), 193-197 (1997).

    4. Kobayashi, Y., Suzuki, M., Ohshiro, N., et al. Climbazole is a new potent inducer of rat hepatic cytochrome P450. J. Toxicol. Sci. 26(3), 141-150 (2001).