An α2-adrenergic receptor antagonist
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Piperoxan (hydrochloride)

Item No. 27629

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-piperidine, monohydrochloride
CAS Number
135-87-5
Synonyms
  • DL-Piperoxan
Molecular Formula
C14H19NO2 • HCl
Formula Weight
269.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
220, 277, 283 nm
SMILES
C12=CC=CC=C1OC(CN3CCCCC3)CO2.Cl
InChi Code
InChI=1S/C14H19NO2.ClH/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12;/h2-3,6-7,12H,1,4-5,8-11H2;1H
InChi Key
BITRJBQGQMGGQI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $158

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    50 mg

    $609

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    100 mg

    $1,042

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    Product Description

    Piperoxan is an α2-adrenergic receptor (α2-AR) antagonist (Kis = 5.4, 2, and 1.3 nM for α2A-, α2B-, and α2C-ARs, respectively) and a first generation histamine receptor antagonist.1,2 It reverses decreases in systolic blood pressure induced by clonidine (Item No. 15949) in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blaxall, H.S., Murphy, T.J., Baker, J.C., et al. Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line. J. Pharmacol. Exp. Ther. 259(1), 323-329 (1991).

    2. Parsons, M.E., and Ganellin, C.R. Histamine and its receptors. Br. J. Pharmacol. 147(Suppl. 1), S127-S135 (2006).

    3. Robson, R.D., Antonaccio, M.J., Saelens, J.K., et al. Antagonism by mianserin and classical α-adrenoceptor blocking drugs of some cardiovascular and behavioral effects of clonidine. Eur. J. Pharmacol. 47(4), 431-442 (1978).