A dual-site covalent antagonist of PPARγ
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SR 16832

Item No. 27632

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-(6-methoxy-4-quinolinyl)-5-nitro-benzamide
CAS Number
2088135-12-8
Molecular Formula
C17H12ClN3O4
Formula Weight
357.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
233 nm
SMILES
COC1=CC=C2C(C(NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)=CC=N2)=C1
InChi Code
InChI=1S/C17H12ClN3O4/c1-25-11-3-5-15-13(9-11)16(6-7-19-15)20-17(22)12-8-10(21(23)24)2-4-14(12)18/h2-9H,1H3,(H,19,20,22)
InChi Key
CVTZAGCRUDYUGB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $40

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    5 mg

    $105

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    10 mg

    $190

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    25 mg

    $423

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    Product Description

    SR 16832 is a dual-site covalent antagonist of peroxisome proliferator-activated receptor γ (PPARγ).1 It inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells when used at a concentration of 5 μM. SR 16832 also reduces basal activity of PPARγ and inhibits binding of docosahexaenoic acid (DHA; Item No. 90310) to PPARγ in a time-resolved FRET (TR-FRET) assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brust, R., Lin, H., Fuhrmann, J., et al. Modification of the orthosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem. Biol. 12(4), 969-978 (2017).