A CCR4 receptor antagonist
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AZD 2098

Item No. 27633

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dichloro-N-(3-methoxy-2-pyrazinyl)-benzenesulfonamide
CAS Number
566203-88-1
Molecular Formula
C11H9Cl2N3O3S
Formula Weight
334.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
222 nm
SMILES
COC1=NC=CN=C1NS(C2=C(Cl)C(Cl)=CC=C2)(=O)=O
InChi Code
InChI=1S/C11H9Cl2N3O3S/c1-19-11-10(14-5-6-15-11)16-20(17,18)8-4-2-3-7(12)9(8)13/h2-6H,1H3,(H,14,16)
InChi Key
FLSMVCMSUNISFK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    AZD 2098 is a CC chemokine receptor 4 (CCR4) antagonist.1 AZD 2098 inhibits CCL22-induced calcium flux in CHO cells expressing human recombinant CCR4 (IC50 = 31.6 nM) and CCL22- and CCL17-mediated Th2 cell chemotaxis (IC50 = 501.2 nM for both). AZD 2098 is selective for CCR4 over CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, and CCR8 up to 10 µM in vitro. Administration of AZD 2098 (0.07-2.5 mg/kg, p.o.) to ovalbumin-sensitized, antigen-challenged rats reduces alveolitis and leukocyte infiltration in the lung in a dose-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kindon, N.D., Andrews, G., Baxter, A., et al. Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists. Med. Chem. 8(9), 981-986 (2017).