An antagonist of CRTH2/DP2
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BI-671800

Item No. 27638

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]-5-pyrimidineacetic acid
CAS Number
1093108-50-9
Synonyms
  • AP-761
Molecular Formula
C25H26F3N5O3
Formula Weight
501.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
251, 279 nm
SMILES
CN(C)C1=NC(CC2=CC=C(NC(C3=CC=C(C(F)(F)F)C=C3)=O)C=C2)=NC(N(C)C)=C1CC(O)=O
InChi Code
InChI=1S/C25H26F3N5O3/c1-32(2)22-19(14-21(34)35)23(33(3)4)31-20(30-22)13-15-5-11-18(12-6-15)29-24(36)16-7-9-17(10-8-16)25(26,27)28/h5-12H,13-14H2,1-4H3,(H,29,36)(H,34,35)
InChi Key
XEOSTBFUCNZKGS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $300

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    10 mg

    $524

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    Product Description

    BI-671800 is an antagonist of the prostaglandin D2 (PGD2; Item No. 12010) receptor CRTH2/DP2 (IC50 = 42 nM in a radioligand binding assay).1 It binds selectively to CRTH2/DP2 over DP1, thromboxane, and prostacyclin receptors (IC50s = 25.6, 62.6, and >100 μM, respectively). BI-671800 inhibits PGD2-induced shape change in human eosinophils (IC50 = 744 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stearns, B.A., Baccei, C., Bain, G., et al. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. Bioorg. Med. Chem. Lett. 19(16), 4647-4651 (2009).