An inhibitor of tubulin polymerization
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Product Categories

Product Type

Biochemicals
Microtubule Dynamics

Research Area

Cancer
Cell Death
Apoptosis

CHM-1

Item No. 27647

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(2-fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one
CAS Number
154554-41-3
Synonyms
  • NSC 656158
Molecular Formula
C16H10FNO3
Formula Weight
283.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
228, 256, 326 nm
SMILES
O=C(C=C(C1=C(F)C=CC=C1)N2)C3=C2C=C(OCO4)C4=C3
InChi Code
InChI=1S/C16H10FNO3/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12/h1-7H,8H2,(H,18,19)
InChi Key
ZMYDAPJHGNEFGQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $157

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    Cayman Chemical
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    Product Description

    CHM-1 is an inhibitor of tubulin polymerization (IC50 = 0.68 µM) with anticancer activity.1 It inhibits colchicine (Item No. 9000760) tubulin binding by 39% when used at a concentration of 5 µM. CHM-1 inhibits the growth of K562, NCI H226, HCT116, OVCAR-3, RXF 393L, SK-MEL-5, SF-268, and SF-295 cancer cells (mean GI50 = 130 nM). It induces apoptosis in HA22T hepatocellular carcinoma cells in a concentration-dependent manner.2 CHM-1 (10 mg/kg) reduces tumor volume and increases survival in an HA22T mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xia, Y., Yang, Z.-Y., Xia, P., et al. Antitumor agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. J. Med. Chem. 44(23), 3932-3936 (2001).

    2. Wang, S.-W., Pan, S.-L., Huang, Y.-C., et al. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol. Cancer Ther. 7(2), 350-360 (2008).