A VEGFR2 inhibitor
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DMH4

Item No. 27653

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl-pyrazolo[1,5-a]pyrimidine
CAS Number
515880-75-8
Molecular Formula
C24H24N4O2
Formula Weight
400.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
290 nm
SMILES
C1(OCCN2CCOCC2)=CC=C(C(C=N3)=CN4C3=C(C5=CC=CC=C5)C=N4)C=C1
InChi Code
InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
InChi Key
SKZQZGSPYYHTQG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $50

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    5 mg

    $134

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    10 mg

    $218

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    25 mg

    $481

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    Product Description

    DMH4 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.16 µM in a cell-free assay) and a derivative of dorsomorphin (Item No. 11967).1 It selectively inhibits VEGFR2 over activin receptor-like kinase 2 (ALK2), ALK5, and AMPK (IC50s = 3.5, >30, and 8 µM, respectively, in a cell-free assay). DMH4 inhibits growth of H460 and A549 human lung cancer cells (GI50s = 13.3 and 2.8 µM, respectively) and reduces VEGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs; IC50 = 1 µM).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hao, J., Ho, J.N., Lewis, J.A., et al. In vivo structure activity relationship study of dorsomorphin analogs identifies selective VEGF and BMP inhibitors. ACS Chem. Biol. 5(2), 245-253 (2010).

    2. Li, H., Ha, H.L., Ding, X., et al. DMH4, a VEGFR2 inhibitor, effectively suppresses growth and invasion of lung cancer cells. J. Appl. Biomed. 16(1), 46-50 (2018).