Rec 15/2615 (hydrochloride)

Rec 15/2615 is an antagonist of α_1B-adrenergic receptors (α_1B-ARs; K_i = 0.45 nM for the recombinant human receptor).¹ It selectively inhibits α_1B-ARs over α_1A-, α_1D-, and α_1L-ARs (K_is = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (K_is = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (K_i = 50 nM).² It decreases diastolic blood pressure (ED₂₅ = 183 µg/kg, i.v.) and increases intracavernous pressure in anesthetized dogs when administered intracavernously at doses ranging from 30 and 1,000 µg/kg.^1,2

WARNING This product is not for human or veterinary use.

1. Sironi, G., Colombo, D., Poggesi, E., et al. Effects of intracavernous administration of selective antagonists of α1-adrenoceptor subtypes on erection in anesthetized rats and dogs. J. Pharmacol. Exp. Ther. 292(3), 974-981 (2000).

2. Testa, R., Guarneri, L., Angelico, P., et al. Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): Role of the alpha-1L adrenoceptor in tissue selectivity, part II. J. Pharmacol. Exp. Ther. 281(3), 1284-1293 (1997).