A triterpenoid
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Ganoderenic Acid A

Item No. 27685

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7β,15α,20E)-7,15-dihydroxy-3,11,23-trioxo-lanosta-8,20(22)-dien-26-oic acid
CAS Number
100665-40-5
Molecular Formula
C30H42O7
Formula Weight
514.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
247 nm
SMILES
CC12C(C[C@H](O)C(C([C@@H](O)CC3/C(C)=C\C(CC(C)C(O)=O)=O)(C)C3(C)C4)=C2C4=O)C(C)(C)C(CC1)=O
InChi Code
InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h10,16,18-19,21,23,32,35H,8-9,11-14H2,1-7H3,(H,36,37)/b15-10-/t16?,18?,19-,21?,23-,28?,29?,30?/m0/s1
InChi Key
OVUOUFPIPZJGME-WHWWCJHXSA-N
Origin
Fungus/Ganoderma lucidum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Ganoderenic acid A is a triterpenoid originally isolated from G. lucidum that has enzyme inhibitory activities.1,2,3 It is an inhibitor of β-glucuronidase (IC50 = 0.12 mg/ml in rat liver microsomes).2 Ganoderenic acid A (100 mg/kg) reduces increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in a rat model of liver injury induced by carbon tetrachloride (CCl4). It also inhibits aldose reductase by 54.2% when used at a concentration of 100 µg/ml.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Komoda, Y., Nakamura, H., Ishihara, S., et al. Structures of new terpenoid constituents of Ganoderma lucidum (Fr.) KARST (Polyporaceae). Chem. Pharm. Bull. 33(11), 4829-4835 (1985).

    2. Kim, D.-H., Shim, S.-B., Kim, N.-J., et al. β-Glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum. Biol. Pharm. Bull. 22(2), 162-164 (1999).

    3. Fatmawati, S., Shimizu, K., and Kondo, R. Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum. Planta Med. 76(15), 1691-1693 (2010).