A triterpenoid with diverse biological activities
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Ganoderic Acid C1

Item No. 33212

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7β,25R)-7-hydroxy-3,11,15,23-tetraoxo-lanost-8-en-26-oic acid
CAS Number
95311-97-0
Molecular Formula
C30H42O7
Formula Weight
514.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
253 nm
SMILES
C[C@]12C3=C(C(C[C@@]1([C@]([C@@H](CC(C[C@@H](C)C(O)=O)=O)C)([H])CC2=O)C)=O)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])C[C@@H]3O)C
InChi Code
InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,32H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,28+,29-,30+/m1/s1
InChi Key
YTVGSCZIHGRVAV-NJNFCIENSA-N
Origin
Fungus/Ganoderma lucidum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Ganoderic acid C1 is a triterpenoid that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It inhibits angiotensin-converting enzyme (ACE; IC50 = 745 µM).2 Ganoderic acid C1 also inhibits HIV-1 protease with an IC50 value of 180 µM.1 It reduces the proliferation of murine Lewis lung carcinoma cells but not murine Meth-A sarcoma cells (EC50s = 17 and >20 µg/ml, respectively).3 Ganoderic acid C1 (20 µg/ml) inhibits LPS-induced NF-κB phosphorylation and production of TNF-α in RAW 264.7 cells, as well as in peripheral blood mononuclear cells (PBMCs) isolated from patients with asthma.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. El-Mekkawy, S., Meselhy, M.R., Nakamura, N., et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49(6), 1651-1657 (1998).

    2. Hai-Bang, T., and Shimizu, K. Structure–activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme. Phytochem. Lett. 12, 243-247 (2015).

    3. Min, B.S., Gao, J.J., Nakamura, N., et al. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem. Pharm. Bull. (Tokyo) 48(7), 1026-1033 (2000).

    4. Liu, C., Yang, N., Song, Y., et al. Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients. Int. Immunopharmacol. 27(2), 224-231 (2015).