A synthetic peptide with neuroprotective, analgesic, and anxiolytic properties
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Semax

Item No. 27719

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline
CAS Number
80714-61-0
Synonyms
  • ACTH4-7-PGP
Molecular Formula
C37H51N9O10S
Formula Weight
813.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC([C@H]1N(C(CNC([C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCSC)=O)CCC(O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)CCC2)=O)=O)CCC1)=O
InChi Code
InChI=1S/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26-,27-,28-,29-/m0/s1
InChi Key
AFEHBIGDWIGTEH-AQRCPPRCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $164

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    5 mg

    $697

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    10 mg

    $1,066

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    Product Description

    Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) (4-10) (Item No. 27106) that has neuroprotective, analgesic, and anxiolytic properties.1,2,3 In vivo, semax (0.3 mg/kg) reduces cortical nitric oxide (NO) production and the number of neurological disturbances, such as seizures, falling, and twisting, in a rat model of global ischemia.1 It decreases acetic acid-induced writhing and nociception in a hind paw compression test in mice when administered at doses ranging from 0.015 to 0.5 mg/kg.2 Semax also increases time spent in the open arms in the elevated plus maze, indicating anxiolytic activity, in a rat model of maternal deprivation-induced anxiety.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bashkatova, V.G., Koshelev, V.B., Fadyukova, O.E., et al. Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia. Brain Res. 894(1), 145-149 (2001).

    2. Ivanova, D.M., Levitskaya, N.G., Andreeva, L.A., et al. Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax. Bull. Exp. Biol. Med. 143(1), 5-8 (2007).

    3. Volodina, M.A., Sebentsova, E.A., Glazova, N.Y., et al. Semax attenuates the influence of neonatal maternal deprivation on the behavior of adolescent white rats. Bull. Exp. Biol. Med. 152(5), 560-563 (2012).