An internal standard for the quantification of (±)-baclofen
Related Products
Unlabeled Version(s)
18600(±)-Baclofen 27326(±)-Baclofen
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(±)-Baclofen-d4

Item No. 27811

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-3-(4-chlorophenyl-2,3,5,6-d4)butanoic acid
CAS Number
1189938-30-4
Molecular Formula
C10H8ClD4NO2
Formula Weight
217.7
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
ClC1=C([2H])C([2H])=C(C(CN)CC(O)=O)C([2H])=C1[2H]
InChi Code
InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/i1D,2D,3D,4D
InChi Key
KPYSYYIEGFHWSV-RHQRLBAQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $588

    Add
    Product Description

    (±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen (Item No. 18600) by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hill, D.R., and Bowery, N.G. 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain. Nature 290(5802), (1981).

    2. Biscoe, T.J., and Fry, J.P. Some pharmacological studies on the spastic mouse. Br. J. Pharmacol. 75(1), 23-25 (1982).

    3. Sakitani, K. The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats. Jpn. J. Pharmacol. 63(3), 369-376 (1993).

    4. Lhuillier, L., Mombereau, C., Cryan, J.F., et al. GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaine. Neuropsychopharmacology 32(2), 388-398 (2007).

    5. Moore, E.M., and Boehm, S.L., II Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice. Behav. Neurosci. 123(3), 555-563 (2009).