An inactive metabolite of (S)-duloxetine
Related Products
Parent Compound(s)
14317(S)-Duloxetine (hydrochloride)
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4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)

Item No. 27823

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]-1-naphthalenyl, β-D-glucopyranosiduronic acid, monosodium salt
Synonyms
  • LY550408
Molecular Formula
C24H26NO8S • Na
Formula Weight
511.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
CNCC[C@@H](C1=CC=CS1)OC2=CC=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C([O-])=O)O3)C4=CC=CC=C42.[Na+]
InChi Code
InChI=1S/C24H27NO8S.Na/c1-25-11-10-17(18-7-4-12-34-18)31-15-8-9-16(14-6-3-2-5-13(14)15)32-24-21(28)19(26)20(27)22(33-24)23(29)30;/h2-9,12,17,19-22,24-28H,10-11H2,1H3,(H,29,30);/q;+1/p-1/t17-,19-,20-,21+,22-,24+;/m0./s1
InChi Key
MZPFENUQRVOCPK-YIHBCKSISA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $502

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    Product Description

    4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine (Item No. 14317).1 It is formed via metabolism of (S)-duloxetine by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6 followed by glucuronidation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Knadler, M.P., Lobo, E., Chappell, J., et al. Duloxetine: Clinical pharmacokinetics and drug interactions. Clin. Pharmacokinet. 50(5), 281-294 (2011).