An oxindole alkaloid with diverse biological activities
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Corynoxine B

Item No. 27827

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αE,1′R,6′S,7′S,8′aS)-6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, methyl ester
CAS Number
17391-18-3
Synonyms
  • Cory B
  • 7-Isocorynoxine
Molecular Formula
C22H28N2O4
Formula Weight
384.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CC[C@H]1[C@@H](/C(C(OC)=O)=C\OC)C[C@]2([H])N(CC[C@@]23C(C=CC=C4)=C4NC3=O)C1
InChi Code
InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22-/m1/s1
InChi Key
DAXYUDFNWXHGBE-XYEDMTIPSA-N
Origin
Plant/Uncariarhynchophylla sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $76

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    5 mg

    $247

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    10 mg

    $456

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    25 mg

    $1,044

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    Product Description

    Corynoxine B is an oxindole alkaloid that has been found in M. speciosa and has diverse biological activities.1,2,3,4,5 It induces autophagy in Drosophila second instar larvae when used at a concentration of 100 µM.2 Corynoxine B (100 mg/kg) inhibits apomorphine- and methamphetamine-induced hyperlocomotion in mice.3 It increases the duration of thiopental-induced sleep in mice when administered at a dose of 100 mg/kg.4 Exosomes containing corynoxine B increase the length of freezing time induced by footshock in a contextual fear conditioning test, decrease the latency to escape in the Morris water maze, and increase the number of hippocampal synaptic connections in the 5XFAD transgenic mouse model of Alzheimer's disease.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chakraborty, S., Uprety, R., Daibani, A.E., et al. Kratom alkaloids as probes for opioid receptor function: Pharmacological characterization of minor indole and oxindole alkaloids from kratom. ACS Chem. Neurosci. 12(14), 2661-2678 (2021).

    2. Chen, L.-L., Song, J.-X., Lu, J.-H., et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J. Neuroimmune Pharmacol. 9(3), 380-387 (2014).

    3. Sakakibara, I., Terabayashi, S., Kubo, M., et al. Effect on locomotion of indole alkaloids from the hooks of Uncaria plants. Phytomedicine 6(3), 163-168 (1999).

    4. Sakakibara, I., Takahashi, H., Terabayashi, S., et al. Effect of oxindole alkaloids from the hooks of Uncaria macrophylla on thiopental-induced hypnosis. Phytomedicine 5(2), 83-86 (1998).

    5. Iyaswamy, A., Thakur, A., Guan, X.J., et al. Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease. Signal Transduct. Target. Ther. 8(1), 404 (2023).