Corynoxine (hydrochloride)

Corynoxine is an indole alkaloid that has been found in U. macrophylla and has neuroprotective activity.^1,2 It increases levels of the autophagy marker LC3-II in Neuro2a and SH-SY5Y neuronal cells when used at concentrations ranging from 6.25 to 25 µM.¹ Corynoxine (25 µM) increases degradation of wild-type and A53T mutant α-synuclein, a major component of Lewy bodies in the brain of Parkinson’s disease patients, in PC12 cells, an effect that can be reversed by the autophagy inhibitors 3-methyladenine (Item No. 13242) and chloroquine (Item No. 14194). It reduces increases in methamphetamine-induced locomotor activity in rats when administered at doses of 30 and 100 mg/kg.²

WARNING This product is not for human or veterinary use.

1. Chen, L.-L., Song, J.-X., Lu, J.-H., et al. Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway. J. Neuroimmune Pharmacol. 9(3), 380-387 (2014).

2. Sakakibara, I., Terabayashi, S., Kubo, M., et al. Effect on locomotion of indole alkaloids from the hooks of Uncaria plants. Phytomedicine 6(3), 163-168 (1999).

Lei, S., Lu, J., Cheng, A., et al. Identification of PXR activators from Uncaria rhynchophylla (Gou Teng) and Uncaria tomentosa (cat’s claw). Drug Metab. Dispos. 51(5), 629-636 (2023).