A natural non-caloric sweetener
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Rebaudioside D

Item No. 27880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4α)-13-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-β-D-glucopyranosyl)oxy]-kaur-16-en-18-oic acid, 2-O-β-D-glucopyranosyl-β-D-glucopyranosyl ester
CAS Number
63279-13-0
Synonyms
  • Reb D
Molecular Formula
C50H80O28
Formula Weight
1129.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C[C@]([C@]1([H])CC2)(CCC[C@@]1(C)C(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O[C@@]4([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)O[C@@H]3CO)=O)[C@@]5([H])[C@]2(CC6=C)C[C@@]6(O[C@@](O[C@H](CO)[C@@H](O)[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@H]8CO)([H])[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]9O)O)([H])O[C@@H]9CO)CC5
InChi Code
InChI=1S/C50H80O28/c1-18-11-49-9-5-24-47(2,7-4-8-48(24,3)46(68)77-44-39(34(64)29(59)22(15-54)72-44)75-42-36(66)32(62)27(57)20(13-52)70-42)25(49)6-10-50(18,17-49)78-45-40(76-43-37(67)33(63)28(58)21(14-53)71-43)38(30(60)23(16-55)73-45)74-41-35(65)31(61)26(56)19(12-51)69-41/h19-45,51-67H,1,4-17H2,2-3H3/t19-,20-,21-,22-,23-,24+,25+,26-,27-,28-,29-,30-,31+,32+,33+,34+,35-,36-,37-,38+,39-,40-,41+,42+,43+,44+,45+,47-,48-,49-,50+/m1/s1
InChi Key
RPYRMTHVSUWHSV-CUZJHZIBSA-N
Origin
Plant/Stevia rebaudiana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $308

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    10 mg

    $520

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    25 mg

    $1,055

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    Product Description

    Rebaudioside D is a natural non-caloric sweetener.1,2 It is a steviol glycoside that has been found in S. rebaudiana leaves. Rebaudioside D, similarly to rebaudioside A (Item No. 11894) and rebaudioside C (Item No. 11895), is metabolized by gut microbiota to steviol (Item No. 10011344), a compound whose safety is widely studied.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, L., Sun, P., Zhou, F., et al. Synthesis of rebaudioside D, using glycosyltransferase UGTSL2 and in situ UDP-glucose regeneration. Food Chem. 259, 286-291 (2018).

    2. Prakash, I., Campbell, M., and Chaturvedula, V.S.P. Catalytic hydrogenation of the sweet principles of Stevia rebaudiana, Rebaudioside B, Rebaudioside C, and Rebaudioside D and sensory evaluation of their reduced derivatives. Int. J. Mol. Sci. 13(11), 15126-15136 (2012).

    3. Purkayastha, S., Markosyan, A., Prakash, I., et al. Steviol glycosides in purified stevia leaf extract sharing the same metabolic fate. Regul. Toxicol. Pharmacol. 77, 125-133 (2016).

    4. Brusick, D.J. A critical review of the genetic toxicity of steviol and steviol glycosides. Food Chem. Toxicol. 46(Suppl 7), S83-S91 (2008).