A dual inhibitor of Cdk8 and Cdk19
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SEL120-34A (hydrochloride)

Item No. 27906

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,8-dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-4H-imidazo[4,5,1-ij]quinoline, hydrochloride
CAS Number
1609452-30-3
Molecular Formula
C15H18Br2N4 • XHCl
Formula Weight
414.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
λmax
228, 259, 300 nm
SMILES
CC1=C(Br)C(Br)=C2C3=C1N=C(N4CCNCC4)N3CCC2.Cl
InChi Code
InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4-18-5-8-20;/h18H,2-8H2,1H3;1H
InChi Key
GQXLWUCQESKBSC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $186

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    10 mg

    $336

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    Product Description

    SEL120-34A is a dual inhibitor of cyclin-dependent kinase 8 (Cdk8) and Cdk19 (IC50s = 4.4 and 10.4 nM, respectively).1 It is selective for Cdk8 and Cdk19 over a panel of CDK/cyclin complexes at 1 µM. SEL120-34A (0.1-5 µM) inhibits IFN-γ-induced phosphorylation of STAT1 in HCT116 colon cancer cells and the proliferation of various acute myeloid leukemia (AML) cells, including MOLM-16, MV4-11, and KG-1 cells (GI50s = <1 µM). It reduces tumor growth in a KG-1 mouse xenograft model when administered at a dose of 60 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rzymski, T., Mikula, M., Żyłkiewicz, E., et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget 8(20), 33779-33795 (2017).