An Aurora A kinase inhibitor
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LY3295668

Item No. 27914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-2-methyl-4-piperidinecarboxylic acid
CAS Number
1919888-06-4
Synonyms
  • AK-01
Molecular Formula
C24H26ClF2N5O2
Formula Weight
490.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=CC=CC(CN2[C@H](C)C[C@](CC3=C(F)C=CC(NC4=NNC(C)=C4)=N3)(C(O)=O)CC2)=C1F
InChi Code
InChI=1S/C24H26ClF2N5O2/c1-14-10-21(31-30-14)29-20-7-6-18(26)19(28-20)12-24(23(33)34)8-9-32(15(2)11-24)13-16-4-3-5-17(25)22(16)27/h3-7,10,15H,8-9,11-13H2,1-2H3,(H,33,34)(H2,28,29,30,31)/t15-,24-/m1/s1
InChi Key
YQQZZYYQTCPEAS-OYLFLEFRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $372

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    10 mg

    $660

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    25 mg

    $1,238

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    Product Description

    LY3295668 is an inhibitor of Aurora A kinase (IC50 = <1 nM).1 It is selective for Aurora A kinase over a panel of 498 other kinases at 1 µM. LY3295668 (200 nM) induces apoptosis in HeLa cervical cancer cells. It induces cell cycle arrest at the G2 phase in HeLa cells (IC50 = 108 nM). In vivo, LY3295668 (40 mg/kg per day) decreases tumor volume in a patient-derived xenograft (PDX) mouse model of small cell lung cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Du, J., Yan, L., Torres, R., et al. Aurora A-selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells, and shows potent preclinical antitumor efficacy. Mol. Cancer Ther. 18(12), 2207-2219 (2019).