An imidazole antifungal agent
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Labeled Version(s)
27616(±)-Climbazole-d4
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(±)-Climbazole

Item No. 27968

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone
CAS Number
38083-17-9
Synonyms
  • BAY-e 6975
Molecular Formula
C15H17ClN2O2
Formula Weight
292.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
223, 275 nm
SMILES
CC(C)(C)C(C(OC1=CC=C(Cl)C=C1)N2C=NC=C2)=O
InChi Code
InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
InChi Key
OWEGWHBOCFMBLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    (±)-Climbazole is an imidazole antifungal agent.1 It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro.2,3,4 It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.1 (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver.5 Formulations containing climbazole have been used in the treatment of dandruff.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cavana, P., Petit, J.Y., Perrot, S., et al. Efficacy of a 2% climbazole shampoo for reducing Malassezia population sizes on the skin of naturally infected dogs. J. Mycol. Med. 25(4), 268-273 (2015).

    2. Stylianou, M., Kulesskiy, E., Lopes, J.P., et al. Antifungal application of nonantifungal drugs. Antimicrob. Agents Chemother. 58(2), 1055-1062 (2014).

    3. Schmidt, A. In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis. Zentralbl. Veterinarmed. B 44(4), 193-197 (1997).

    4. Schmidt, A., and Rühl-Hörster, B. In vitro susceptibility of Malassezia furfur against azole compounds. Mycoses 39(7-8), 309-312 (1996).

    5. Kobayashi, Y., Suzuki, M., Ohshiro, N., et al. Climbazole is a new potent inducer of rat hepatic cytochrome P450. J. Toxicol. Sci. 26(3), 141-150 (2001).