An active metabolite of lidocaine
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MEGX (hydrochloride)

Item No. 28019

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,6-dimethylphenyl)-2-(ethylamino)-acetamide, monohydrochloride
CAS Number
7729-94-4
Synonyms
  • Monoethylglycinexylidide
  • Norlidocaine
Molecular Formula
C12H18N2O • HCl
Formula Weight
242.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CC1=CC=CC(C)=C1NC(CNCC)=O.Cl
InChi Code
InChI=1S/C12H18N2O.ClH/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3;/h5-7,13H,4,8H2,1-3H3,(H,14,15);1H
InChi Key
KPXFVVHMUVBVGI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $132

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    10 mg

    $246

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    25 mg

    $523

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    Product Description

    MEGX is an active metabolite of lidocaine.1 It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury.2 Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reichel, C., Skodra, T., Nacke, A., et al. The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans. Br. J. Clin. Pharmacol. 46(6), 535-539 (1998).

    2. Luostarinen, V., Evers, H., Lyytikäinen, M.T., et al. Antithrombotic effects of lidocaine and related compounds on laser-induced microvascular injury. Acta Anaesthesiol. Scand. 25(1), 9-11 (1981).