A major inactive metabolite of axitinib
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Parent Compound(s)
13813Axitinib
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Axitinib Sulfoxide

Item No. 28042

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide
CAS Number
1347304-18-0
Molecular Formula
C22H18N4O2S
Formula Weight
402.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(NC)C1=C(S(C2=CC3=C(C(/C=C/C4=NC=CC=C4)=NN3)C=C2)=O)C=CC=C1
InChi Code
InChI=1S/C22H18N4O2S/c1-23-22(27)18-7-2-3-8-21(18)29(28)16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
InChi Key
MAHSNFBPPYMWFB-FMIVXFBMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

    $233

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    Product Description

    Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib (Item No. 13813).1,2 It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zientek, M.A., Goosen, T.C., Tseng, E., et al. In vitro kinetic characterization of axitinib metabolism. Drug Metab. Dispos. 44(1), 102-114 (2016).

    2. Smith, B.J., Pithavala, Y., Bu, H.Z., et al. Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans. Drug Metab. Dispos. 42(5), 918-931 (2014).