An internal standard for the quantification of desoximetasone
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Unlabeled Version(s)
23945Desoximetasone
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Desoximetasone-d3

Item No. 28159

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-11β,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione-d3
Synonyms
  • 17-deoxy Dexamethasone-d3
Molecular Formula
C22H26D3FO4
Formula Weight
379.5
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4([2H])C(C([2H])([2H])O)=O)=C1
InChi Code
InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1/i11D2,19D
InChi Key
VWVSBHGCDBMOOT-BAIJJDIOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $796

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    Product Description

    Desoximetasone-d3 is intended for use as an internal standard for the quantification of desoximetasone (Item No. 23945) by GC- or LC-MS. Desoximetasone is a glucocorticoid.1 In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kowalczyk, P., Junco, J.J., Kowalczyk, M.C., et al. The effects of dissociated glucocorticoids RU24858 and RU24782 on TPA-induced skin tumor promotion biomarkers in SENCAR mice. Mol. Carcinog. 53(6), 488-497 (2014).