A glucocorticoid
Related Products
Isomer(s)
35246Fluocortolone
Labeled Version(s)
28159Desoximetasone-d3
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Desoximetasone

Item No. 23945

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-11β,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
CAS Number
382-67-2
Synonyms
  • A 41-304
  • 17-deoxy Dexamethasone
  • HOE 304
Molecular Formula
C22H29FO4
Formula Weight
376.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 3 mg/ml
λmax
237
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@H]4C(CO)=O)=C1
InChi Code
InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
InChi Key
VWVSBHGCDBMOOT-IIEHVVJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    50 mg

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    Product Description

    Desoximetasone is a glucocorticoid.1 In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kowalczyk, P., Junco, J.J., Kowalczyk, M.C., et al. The effects of dissociated glucocorticoids RU24858 and RU24782 on TPA-induced skin tumor promotion biomarkers in SENCAR mice. Mol. Carcinog. 53(6), 488-497 (2014).