An avermectin with anthelmintic and insecticidal activities
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Eprinomectin

Item No. 28182

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4''R)-4''-(acetylamino)-4''-deoxy-avermectin B1
CAS Number
123997-26-2
Synonyms
  • MK-397
Molecular Formula
C50H75NO14 (for B1a)
Formula Weight
914.1
Purity
≥95% (mixture of B1a and B1b)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
246 nm
SMILES
C/C([C@@H](O[C@@]1([H])C[C@H](OC)[C@@H](O[C@]2([H])O[C@@H](C)[C@@H](NC(C)=O)[C@@H](OC)C2)[C@H](C)O1)[C@@H](C)/C=C/C=C(CO3)/[C@@]([C@@]3([H])[C@H](O)C(C)=C4)(O)[C@]4([H])C5=O)=C\C[C@]6([H])C[C@@](O5)([H])C[C@]7(C=C[C@H](C)[C@]([C@H](CC)C)([H])O7)O6.C/C([C@@H](O[C@@]8([H])C[C@H](OC)[C@@H](O[C@]9([H])O[C@@H](C)[C@@H](NC(C)=O)[C@@H](OC)C9)[C@H](C)O8)[C@@H](C)/C=C/C=C(CO%10)/[C@@]([C@@]%10([H])[C@H](O)C(C)=C%11)(O)[C@]%11([H])C%12=O)=C\C[C@]%13([H])C[C@@](O%12)([H])C[C@]%14(C=C[C@H](C)[C@@H](C(C)C)O%14)O%13
InChi Code
InChI=1S/C50H75NO14.C49H73NO14/c1-12-26(2)45-29(5)18-19-49(65-45)24-36-21-35(64-49)17-16-28(4)44(27(3)14-13-15-34-25-58-47-43(53)30(6)20-37(48(54)61-36)50(34,47)55)62-41-23-39(57-11)46(32(8)60-41)63-40-22-38(56-10)42(31(7)59-40)51-33(9)52;1-25(2)43-28(5)17-18-48(64-43)23-35-20-34(63-48)16-15-27(4)44(26(3)13-12-14-33-24-57-46-42(52)29(6)19-36(47(53)60-35)49(33,46)54)61-40-22-38(56-11)45(31(8)59-40)62-39-21-37(55-10)41(30(7)58-39)50-32(9)51/h13-16,18-20,26-27,29,31-32,35-47,53,55H,12,17,21-25H2,1-11H3,(H,51,52);12-15,17-19,25-26,28,30-31,34-46,52,54H,16,20-24H2,1-11H3,(H,50,51)/b14-13+,28-16+,34-15+;13-12+,27-15+,33-14+/t26-,27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43+,44-,45+,46-,47+,49+,50+;26-,28-,30-,31-,34+,35-,36-,37-,38-,39-,40-,41+,42+,43+,44-,45-,46+,48+,49+/m00/s1
InChi Key
VBPOFUHCXIRECN-SXLRFJQHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Product Description

    Eprinomectin is an avermectin with anthelmintic and insecticidal activities.1 It is composed of eprinomectin B1a (Item No. 28130) and eprinomectin B1b (Item No. 27994).2 Eprinomectin (≥0.08 mg/kg, applied topically) reduces worm burden by 99% or more in bovine models of adult H. placei, O. ostertagi, T. axei, Cooperia punctata, N. helvetianus, O. radiatum, or D. viviparus infection.1 It also reduces parasite burden in bovine models of horn fly (H. irritans) or mange mite (C. bovis) infestation, as well as in cows naturally infested with lice (L. vituli), when applied topically at doses ranging from 0.16 to 0.5 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shoop, W.L., Egerton, J.R., Eary, C.H., et al. Eprinomectin: A novel avermectin for use as a topical endectocide for cattle. Int. J. Parasitol. 26(11), 1237-1242 (1996).

    2. Jiang, X., Hao, H.X., Growney, J.D., et al. Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma. Proc. Natl. Acad. Sci. USA 110(31), 12649-12654 (2013).