A trichothecene mycotoxin
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Myrothecine A

Item No. 28193

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,4R,7Z,11S,15E,19aR,22S,23S,23aR,25R,26S,27R)-11-acetyl-3,4,10,11,21,22,23,23a-octahydro-22,25,27-trihydroxy-22,26-dimethyl-20H-11,15-methano-23,2,4,19a-[1,2]propanediyl[3]ylidene-2H,13H,19H-1,5,12,18-benzotetraoxacycloheneicosin-6,17(9H,14H)-dione
CAS Number
910292-40-9
Molecular Formula
C29H38O10
Formula Weight
546.6
Purity
≥70%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: solubleMethanol: soluble
SMILES
O[C@]1(C)CC[C@@]2(COC(/C=C3[C@@H](O)[C@@]4(C(C)=O)OCC\3)=O)[C@@]5([H])[C@]1([H])C[C@@]6(O)[C@]2(C)[C@@](OC(/C=C/CC4)=O)([H])C[C@@]6([H])O5
InChi Code
InChI=1S/C29H38O10/c1-16(30)28-8-5-4-6-21(31)38-19-13-20-29(35)14-18-24(39-20)27(26(19,29)3,10-9-25(18,2)34)15-36-22(32)12-17(23(28)33)7-11-37-28/h4,6,12,18-20,23-24,33-35H,5,7-11,13-15H2,1-3H3/b6-4+,17-12-/t18-,19+,20+,23+,24+,25+,26+,27+,28+,29-/m0/s1
InChi Key
HGVKMRAJPCHSPC-MAJSWSFESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $395

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    Product Description

    Myrothecine A is a trichothecene mycotoxin that has been found in M. roridum and has anticancer activities.1,2 It inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells (IC50s = 95, 70, 60, and 25 µM, respectively).1 Myrothecine A (50 µM) induces G1 cell cycle arrest in HepG2 cells, as well as increases Bax and cleaved caspase-3, -5, and -8 levels and induces apoptosis in SMMC-7721 cells.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, T., Wang, G., Zhou, Y., et al. Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum. J. Agric. Food Chem. 62(25), 5993-6000 (2014).

    2. Song, H., Fu, Y., Wan, D., et al. Mytoxin B and myrothecine A induce apoptosis in human hepatocarcinoma cell line SMMC-7721 via PI3K/Akt signaling pathway. Molecules 24(12), E2291 (2019).