An internal standard for the quantification of sumatriptan
Related Products
Unlabeled Version(s)
14600Sumatriptan (succinate)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Sumatriptan-d6 (succinate)

Item No. 28202

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[2-[di(methyl-d3)amino]ethyl]-N-methyl-1H-indole-5-methanesulfonamide, butanedioic acid (2:1)
CAS Number
1397195-80-0
Molecular Formula
C14H15D6N3O2S • 1/2C4H6O4
Formula Weight
360.4
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(CCC(O)=O)O.CNS(CC1=CC=C(NC=C2CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C2=C1)(=O)=O.CNS(CC3=CC=C(NC=C4CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C4=C3)(=O)=O
InChi Code
InChI=1S/2C14H21N3O2S.C4H6O4/c2*1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h2*4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)/i2*2D3,3D3;
InChi Key
HIMZTGQXEPNRFN-LXRVQIONSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $423

    Add
    Product Description

    Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan (Item No. 14600) by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).1 It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 (Item No. 29651). Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2 Formulations containing sumatriptan have been used in the treatment of migraine headache.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Razzaque, Z., Heald, M.A., Pickard, J.D., et al. Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activation. Br. J. Pharmacol. 47(1), 75-82 (1999).

    2. Pradhan, A., Smith, M.L., McGuire, B., et al. Characterization of a novel model of chronic migraine. Pain 155(2), 269-274 (2014).