A fluorogenic substrate for caspase-8
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Alternative(s)
27101Z-IETD-AFC
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(Z-IETD)2-Rh 110 (trifluoroacetate salt)

Item No. 28212

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5S,5’S,8S,8’S,11S,11’S,14S,14’S)-14,14’-(((3-oxo-3H-spiro[isobenzofuran-1,9’-xanthene]-3’,6’-diyl)bis(azanediyl))bis(carbonyl))bis(5-((S)-sec-butyl)-8-(2-carboxyethyl)-11-((R)-1-hydroxyethyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oic acid), trifluoroacetate salt
Synonyms
  • (Z-Ile-Glu-Thr-Asp)2-R110
  • Rhodamine 110 bis-(N-CBZ-IETD)2
Molecular Formula
C74H86N10O25 • XCF3COOH
Formula Weight
1515.5
Purity
≥95%
Emission
520 nm
Excitation
496 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml
SMILES
OC(C[C@H](NC([C@](NC([C@@H](NC([C@@]([C@@H](C)CC)([H])NC(OCC1=CC=CC=C1)=O)=O)CCC(O)=O)=O)([H])[C@@H](C)O)=O)C(NC2=CC=C(C3(C(C=CC=C4)=C4C(O3)=O)C(C=CC(NC([C@H](CC(O)=O)NC([C@@](NC([C@H](CCC(O)=O)NC([C@]([C@H](CC)C)(NC(OCC5=CC=CC=C5)=O)[H])=O)=O)([C@H](O)C)[H])=O)=O)=C6)=C6O7)C7=C2)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C74H86N10O25.C2HF3O2/c1-7-37(3)59(83-72(104)106-35-41-17-11-9-12-18-41)67(99)77-49(27-29-55(87)88)63(95)81-61(39(5)85)69(101)79-51(33-57(91)92)65(97)75-43-23-25-47-53(31-43)108-54-32-44(24-26-48(54)74(47)46-22-16-15-21-45(46)71(103)109-74)76-66(98)52(34-58(93)94)80-70(102)62(40(6)86)82-64(96)50(28-30-56(89)90)78-68(100)60(38(4)8-2)84-73(105)107-36-42-19-13-10-14-20-42;3-2(4,5)1(6)7/h9-26,31-32,37-40,49-52,59-62,85-86H,7-8,27-30,33-36H2,1-6H3,(H,75,97)(H,76,98)(H,77,99)(H,78,100)(H,79,101)(H,80,102)(H,81,95)(H,82,96)(H,83,104)(H,84,105)(H,87,88)(H,89,90)(H,91,92)(H,93,94);(H,6,7)/t37-,38-,39+,40+,49-,50-,51-,52-,59-,60-,61-,62-;/m0./s1
InChi Key
UUTKUGGZGIYRMX-REXNWUKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    (Z-IETD)2-Rh 110 is a fluorogenic substrate for caspase-8.1 Upon enzymatic cleavage by caspase-8, rhodamine 110 (Item No. 19061) is released and its fluorescence can be used to quantify caspase-8 activity. Rhodamine 110 displays excitation/emission maxima of 496/520 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baumgartner, H.K., Gerasimenko, J.V., Thorne, C., et al. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am. J. Physiol. Gastrointest. Liver Physiol. 293(1), 296-307 (2007).