A fluorogenic caspase substrate
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(D)2-Rh 110 (trifluoroacetate salt)

Item No. 28213

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,3'S)-4,4'-[(3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl)diimino]bis[3-amino-4-oxo-butanoic acid, trifluoroacetate salt
Synonyms
  • D2R, (Asp)2-Rhodamine 110
  • Rhodamine 110 bis-(L-aspartic acid amide)
Molecular Formula
C28H24N4O9 • XCF3COOH
Formula Weight
560.5
Purity
≥95%
Emission
520 nm
Excitation
496 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C([C@@H](N)CC(O)=O)NC1=CC=C(C2(C(C=CC=C3)=C3C(O2)=O)C(C=CC(NC([C@@H](N)CC(O)=O)=O)=C4)=C4O5)C5=C1.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C28H24N4O9.C2HF3O2/c29-19(11-23(33)34)25(37)31-13-5-7-17-21(9-13)40-22-10-14(32-26(38)20(30)12-24(35)36)6-8-18(22)28(17)16-4-2-1-3-15(16)27(39)41-28;3-2(4,5)1(6)7/h1-10,19-20H,11-12,29-30H2,(H,31,37)(H,32,38)(H,33,34)(H,35,36);(H,6,7)/t19-,20-;/m0./s1
InChi Key
KIHCZYKJFWQUGV-FKLPMGAJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $173

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    Product Description

    (D)2-Rh 110 is a fluorogenic caspase substrate.1 Upon enzymatic cleavage by caspases, rhodamine 110 (Item No. 19061) is released in an apoptosis-dependent manner and its fluorescence can be used to quantify caspase activity. Rhodamine 110 displays excitation/emission maxima of 496/520 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hug, H., Los, M., Hirt, W., et al. Rhodamine 110-linked amino acids and peptides as substrates to measure caspase activity upon apoptosis induction in intact cells. Biochemistry 38(42), 13906-13911 (1999).