A polypeptide antibiotic mixture
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Gramicidin

Item No. 28251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1405-97-6
Synonyms
  • Gramicidin D
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: slightly soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $236

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    Product Description

    Gramicidin is a polypeptide antibiotic mixture of gramicidin A (Item No. 26384), gramicidin B, and gramicidin C originally isolated from B. brevis.1 It is also a component of the antibiotic tyrothricin (Item No. 22177).2 Gramicidin is active against the Gram-positive bacterium S. aureus but not Gram-negative E. coli.3 It also protects mice from Pneumococcus infection in vivo when administered at a dose of 0.002 mg/animal. Gramicidin inhibits growth of bacteria by forming pores and channels in the cell wall, which increases its permeability to monovalent cations.1 Formulations containing gramicidin have been used as topical agents in the treatment of bacterial skin infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wallace, B.A. Gramicidin channels and pores. Annu. Rev. Biophys. Biophys. Chem. 19, 127-157 (1990).

    2. Brewer, G.A. Gramicidin. Analytical profiles of drug substances 8, 179-218 (1979).

    3. Dubos, R.J., and Hotchkiss, R.D. The production of bactericidal substances by aerobic sporulating bacilli. J. Exp. Med. 73(5), 629-640 (1941).