A CK1 inhibitor
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CKI-7 (hydrochloride)

Item No. 28268

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-aminoethyl)-5-chloro-8-isoquinolinesulfonamide, dihydrochloride
CAS Number
1177141-67-1
Molecular Formula
C11H12ClN3O2S • 2HCl
Formula Weight
358.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly solubleWater: Sparingly soluble (heated)
SMILES
ClC1=C(C=CN=C2)C2=C(S(NCCN)(=O)=O)C=C1.Cl.Cl
InChi Code
InChI=1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H
InChi Key
JUAVTXYOCISSSL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $178

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    10 mg

    $259

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    25 mg

    $587

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    Product Description

    CKI-7 is an inhibitor of casein kinase 1 (CK1; Ki = 8.5 μM).1 It is selective for CK1 over CK2, PKC, CaM kinase II (CaMKII), and cyclic AMP-dependent protein kinase (IC50s = 90, >1,000, 195, and 550 μM, respectively). CKI-7 inhibits phosphorylation of a peptide substrate by Leishmania CK1.2 by 50% when used at a concentration of 10 μM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chijiwa, T., Hagiwara, M., and Hidaka, H. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. The Journal of Biological Chemisty 264(9), 4924-4927 (1989).

    2. Rachidi, N., Taly, J.F., Durieu, E., et al. Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection. Antimicrob. Agents Chemother. 58(3), 1501-1515 (2014).